United are expected to name a largely unchanged XI against the Canaries at Carrow Road but will be forced into one potentially significant change in the middle of the park.
Ampadu will sit out the next 10 weeks of Championship action after picking up a lateral collateral knee ligament injury against Coventry last weekend. In his place, Ilia Gruev will reprise his role as the 'deep six' leaving the question of whether Joe Rothwell or Ao Tanaka comes into the side for a prolonged spell.
Daniel Farke threw his support behind Mateo Joseph once more in Monday's pre-match press conference following another goal off the bench from Joel Piroe.
Leeds' defensive options now appear decidedly light after it was revealed Wober would undergo knee surgery on an injury to his meniscus.
Here is the starting line-up we expect Farke to name on Tuesday evening.
7. CM: Ao Tanaka
Set to be handed a full debut on Tuesday night at Carrow Road from the No. 8 position. | Getty Images
8. RW: Willy Gnonto
A major threat for this Leeds side, evidenced by his sublime first-time finish at Elland Road on Saturday. | Freelance Photo: Freelance
9. AM: Brenden Aaronson
Busy and effective in spells during Leeds' win over Coventry. Has really found his feet since returning to Elland Road which has curried favour with supporters. Photo: Lewis Storey
10. LW: Largie Ramazani
Considering Manor Solomon and Dan James remain injured, there is no better time for the Belgian winger to make his mark. | Freelance Photo: Freelance
11. ST: Mateo Joseph
Farke has yet again thrown his support behind the young Spaniard who played an important role, despite not getting on the scoresheet, at the weekend. | Jonathan Gawthorpe Photo: Jonathan Gawthorpe