Farke will likely select Willy Gnonto in place of Dan James who limped off at the Riverside Stadium on Tuesday night with a hamstring problem.
Gnonto has struggled with an ankle issue of his own lately but was able to start against Luton Town last Saturday and came off the bench versus Middlesbrough in midweek.
United's boss has tended to rotate mainly when injuries have forced his hand, therefore there is a strong chance the other 10 starts from Tuesday night will remain in place when the teamsheets are released on Saturday morning.
Two players who will not feature at Elland Road this weekend are Joe Rothwell (calf) and Pascal Struijk (foot). The former is out for the next three games, while the result of a scan on Struijk's injured foot will determine whether his season is over or not.
Here is the YEP's predicted XI vs the Deepdale club.
7. CM: Ao Tanaka
Emotionally spent after the last two games but still required in the middle, Tanaka is Farke's preferred choice to partner Gruev with Rothwell out injured and Ampadu playing deeper. Photo: Rhianna Chadwick
8. LW: Manor Solomon
Got the goals and assists monkey off his back at the Riverside, ending an eight-game drought and should have had a second if Tanaka's perfectly legitimate goal had stood. | Getty Images
9. RW: Willy Gnonto
The logical pick to replace James if the Welshman is, as expected, unavailable to start against Preston. Photo: Rhianna Chadwick
10. AM: Brenden Aaronson
Gnonto out wide likely means Aaronson continues in the No. 10 role for as long as James remains sidelined. Photo: George Wood
11. ST: Joel Piroe
Amid calls for Patrick Bamford to return from the start, Piroe probably still gets the nod from Farke because he has the requisite match fitness and rhythm that Bamford lacks, even if the Dutchman is on a goal drought since notching his 15th of the season some weeks ago. Photo: Ben Roberts Photo