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Dan James, Patrick Bamford and Joe Gelhardt are all expected to miss out on Farke's starting line-up as the Pilgrims arrive in LS11.
The former has reported an issue with his hamstring, just as he was overcoming the same problem with recent outings against Sheffield United, Watford and Bristol City.
Bamford, meanwhile, has an adductor problem and scarcely-utilised Gelhardt took a hit in training, according to Farke and has injured his hip.
Junior Firpo does return to the fold following a one-match suspension and is highly likely to do so but Farke must come up with a solution for full-back on the opposite side Jayden Bogle who will miss Plymouth through a suspension of his own.
Here's how the YEP team expects Farke to name his XI on Saturday afternoon.
7. CM: Joe Rothwell
Not quite as impactful in his last two as he was at home to Sheffield United, but with few alternatives to speak of, there is no issue in Farke's mind to keep fielding the Bournemouth loanee. | Getty Images
8. RW: Willy Gnonto
Leeds' bright spark this season is likely to start on the right-hand side of Farke's attack in order to accommodate a more naturally left-sided teammate on the opposite flank. | Robbie Stephenson Photo: Robbie Stephenson
9. AM: Brenden Aaronson
Scored during his last Elland Road outing and should be expected to continue in the side this weekend. | Danny Lawson/PA Wire
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10. LW: Manor Solomon
Largie Ramazani injured or Dan James not ready to start, there can only be one solution on the left flank. | PA
11. ST: Mateo Joseph
Farke fielded the young striker away at Plymouth in the FA Cup last season and may deem this weekend another opportunity to get the striker a goal or two and keep that confidence of his high, particularly after Joel Piroe failed to make an impact last weekend. | Bruce Rollinson