Georginio Rutter, Patrick Bamford, Crysencio Summerville and Dan James are all listed as doubtful for the trip to Chelsea on Wednesday night with Farke keen to protect his most important attackers ahead of Saturday lunchtime's visit to Huddersfield Town in the Championship.
Leeds' primary goal this season is to achieve promotion back to the Premier League, despite the team's cup run which could see them book their place in the quarter final with a surprise victory over defeated Carabao Cup finalists Chelsea this week.
Here is the XI we expect Farke to name at Stamford Bridge.
7. Archie Gray - CM
Gray could replace Glen Kamara in midfield. The latter has been rested by Farke in recent cup outings. | Mike Egerton/PA Wire
8. Jaidon Anthony - LW
Anthony is likely to feature on the left-wing due to a knock picked up by Summerville in the win over Leicester, in addition to Farke's admission that Leeds will not take any risks with key players | Getty Images
9. Willy Gnonto - RW
The Italian should retain his place in the starting line-up considering there are knocks to Summerville and Dan James. | Getty Images
10. Joel Piroe - CF
Piroe remains fit, therefore he is most probably the player Farke chooses for the No. 10 role given Georginio and Patrick Bamford are both doubts. | Getty Images
11. Mateo Joseph - ST
If Bamford or Georginio are unable to play a part on Wednesday night, Farke will choose Joseph to lead the line as he did away at Plymouth in the Fourth Round replay. | Getty Images