The Whites head into the game against the Reds fresh off the back of heavy defeats to Manchester City and Arsenal, and will have to be at their best to secure a positive result against Jurgen Klopp's side.
As things stand, Leeds are 16th in the Premier League table, but could see themselves dragged closer to the relegation zone should the likes of Burnley and Watford capitalise on their upcoming games in hand.
Speaking ahead of this weekend's game, Leeds boss Marcelo Bielsa reflected on the squad's injury woes, and said: “The type of injuries we have had are injuries in the tendons and muscles in the lower part of the feet and in the bones of the shoulders, apart from Bamford who got injured celebrating a goal and [Daniel] James who got injured in the last game.
“They’re not injuries linked to tiredness, the team continues to run as always. On Thursday in the last minute of a practice that was informal, a team-mate fell on Cresswell, who was going to play, it provoked an injury that is complex.”
The player [Llorente] who looks after his health the most in the whole squad, in a squad where all of the players are double or triple vaccinated, gets ill.”
Take a look at today's biggest stories from the Premier League, as the tier sides gear up for the Boxing Day action this weekend:
7. Seagulls tipped to bag Blackburn striker
Brighton & Hove Albion have been named favourites to sign Blackburn Rovers sensation Ben Brereton Diaz, ahead of the likes of Sevilla and Southampton. The Chile international has dazzled for Rovers this season, scoring 19 goals in 23 league games. (Various) Photo: Warren Little
8. Blues ready raid for rapid winger
Chelsea have been linked with a move for former Manchester United youngster Deji Sotona. The rapid winger is currently on the books at OGC Nice, and has represented the Republic of Ireland at youth level. (Telegraph) Photo: Mike Hewitt
9. Race for Rodon intensifies
Leeds United are among a number of sides to be credited with an interest in Spurs defender Joe Rodon. The £15m towering centre-back is also said to be on Brighton and Newcastle's respective radars, with the latter tipped as front-runners to seal the deal. (Telegraph) Photo: Martin Rose
10. Vieira keen on Leeds return
Reports from Italy claim ex-Leeds United midfielder Ronaldo Vieira is ready to "pack his bags" and pursue a move back to the Whites. The Sampdoria man almost joined Sheffield United last summer, but the deal reportedly collapsed following issues with his medical. (Sport Witness) Photo: Jonathan Moscrop