Marcelo Bielsa's side have dropped into the relegation zone following Saturday's 2-1 defeat at home to West Ham which has left Leeds on three points after six games played.
United are one point ahead of second-bottom Burnley who are two points ahead of Norwich City who are yet to pick up a single point.
Based on the best available odds for relegation, we take a look at where the bookies now expect Leeds to finish upon their second season back in the country's top flight.
Leeds stormed to ninth place as a newly-promoted side last term.
1. 1st - Manchester City
Odds for relegation: 2000-1. Odds for the title: 6-5 favourites. Photo by BEN STANSALL/AFP via Getty Images.
2. 2nd - Chelsea
Odds for relegation: 2000-1. Odds for the title: 11-4 second favourites. Photo by BEN STANSALL/AFP via Getty Images.
3. 3rd - Liverpool
Odds for relegation: 2000-1. Odds for the title: 9-2. Photo by GLYN KIRK/AFP via Getty Images.
4. 4th - Manchester United
Odds for relegation: 1000-1. Odds for the title: 12-1. Photo by Gareth Copley/Getty Images.
5. 5th - Tottenham Hotspur
Odds for relegation: 225-1. Odds for the title: 200-1. Photo by David Rogers/Getty Images.
6. 6th - Everton
Odds for relegation: 100-1. Odds for the title: 269-1. Photo by Jan Kruger/Getty Images.