Leeds will be looking to build on Sunday's epic 2-1 victory at home to Norwich City in which Joe Gelhardt struck a 94th-minute winner, just three minutes after Kenny McLean's strike had cancelled out Rodrigo's opener.
Wolves, meanwhile, will be seeking to land a third win on the bounce having followed last Thursday's 4-0 victory at home to Watford with Sunday's 1-0 success at Everton.
Bruno Lage's side have now won seven of their last 11 league games.
Whites boss Marsch held his pre-match press conference on Thursday morning and provided the latest team news, notably a huge double boost concerning England international star Kalvin Phillips and captain Liam Cooper.
The duo have been out since the start of December with hamstring injuries but are both back in full training and in contention to feature.
But left back Junior Firpo is out with an MCL injury, Joe Gelhardt has a slight back issue and both Jamie Shackleton and Lewis Bate picked up knocks playing for the under-23s against Manchester United on Tuesday night.
Rodrigo also came off in last weekend's win against Norwich with a slight quad issue whilst Tyler Roberts is out after tearing his hamstring and Leo Hjelde is on the comeback trail after knee surgery.
After Marsch's updates, this is how we are expecting Leeds to line up at Molineux.
7. CM - Mateusz Klich
It will be fascinating to see who partners Phillips as part of Marsch's double pivot in midfield once the Yorkshire Pirlo is back to the peak of his powers but Klich put in a terrific shift against Norwich and ought to be keeping his place based on that performance.
8. RW - Raphinha
After a dip in form, United's Brazilian star winger bounced back with a bang against Norwich, setting up the winner and twice denied by the bar. One more stellar display would be great before heading away on international duty. Initially lined up on the left against Norwich.
9. LW - Dan James
James was popping up everywhere after lining up on the right hand side of midfield against Norwich, often cutting in to help the front line to good effect. He could start on either side or even upfront but wide left would be the percentage call.
10. ST - Rodrigo
The record signing bounced back from a poor display against Villa by excelling versus the Canaries and netting the opener. The Spaniard went off with a slight quad issue but was set to train on Friday and will likely start if fit although Joe Gelhardt surely won't be long in being a regularly starter.
11. ST - Patrick Bamford
Marsch said Bamford was a bit sore after playing 45 minutes upon his return to the starting XI against Norwich but that's understandable following his injury and spell out. Marsch was hopeful the no 9 would be fine to line up against Wolves and Leeds look so much better when he's up tops.