Leeds are seeking a third Premier League win on the spin having followed up a thrilling 2-1 victory at home to Norwich City with a stunning 3-2 triumph at Wolves, the Whites bagging all three points at Molineux despite seeing four players forced off injured.
Whites no 9 Patrick Bamford is now facing around six weeks out due to a ruptured plantar fascia - an injury to the sole of the foot.
Goalkeeper Illan Meslier, centre-back Diego Llorente and midfielder Mateusz Klich were also forced off at Wolves whilst star winger Raphinha missed the clash at Molineux having tested positive for Covid-19.
But the quartet are all in line to feature against the Saints along with key returning duo Kalvin Phillips and Liam Cooper.
Cooper and Phillips have not featured since both picked up hamstring injuries in the 2-2 draw at home to Brentford on December 5 although the duo both returned to the bench as unused substitutes for the clash at Molineux.
Whites boss Jesse Marsch provided an update regarding the pair at Thursday afternoon's pre-match press conference, saying that neither player was yet fully 90 minutes fit but that both were close.
The Leeds boss said he did not think he could start both players against the Saints as that would mean two substitutions already counted for in the likelihood that both would need to come off.
Marsch also still has Junior Firpo, Jamie Shackleton, Leo Hjelde and Tyler Roberts out injured but teen striker Joe Gelhardt is back in rude health following a recent back spasm and excelled in a training test match this week.
After the latest information from United's head coach, this is how we expect Leeds to line up upon their return to action against Ralph Hasenhuttl's side.
7. CM - Mateusz Klich
Klich has made a very strong start to life under Marsch. The Pole plus Koch and Adam Forshaw are the other main options in centre midfield but Klich and Phillips might be the way that the Whites boss opts to go.
8. RW - Raphinha
United's Brazilian international star missed the win at Wolves due to Covid-19 but he's now back in business and Raphinha was said to have been incredible in a training match this week.
9. LW - Dan James
This is where it gets very tricky, even with Bamford out. James could play upfront but the Wales international has looked menacing out wide of late. That said, if he starts on the left, that means Jack Harrison probably misses out so it's a big call.
10. ST - Rodrigo
The record signing is another player to have made a very bright start under Marsch and the in-form Spaniard looks certain to be in the front line, it's just a question of who partners him.
11. ST - Joe Gelhardt
Cometh the hour, cometh the Joffy. Leeds need someone to lead the line in the absence of Bamford and Gelhardt is a natural striker and a very exciting one too. It could be James up tops but Joffy was being considered as a starter at Wolves and this could be his time.