Ahead of kick-off, we've taken a look back at the last time the Whites triumphed over the Reds back in 2001 - a Premier League classic that saw David O'Leary's side hang on to claim a precious win at Anfield with a 2-1. Here's where every player in the starting XI - from both sides - is now.
1. Nigel Martyn - Leeds United - GK
The former Whites stopper is now long-retired, but is thriving in the amateur cricket scene Knaresborough. A glance at his Play Cricket profile reveals he took 29 catches last season. Photo: Gareth Copley
2. Sander Westerveld - Liverpool - GK
Westervelt went on to play for a host of other sides including Real Sociedad and Portsmouth, before ending his career with South African outfit Ajax Cape Town - he's now a goalkeeping coach there. Photo: Gallo Images
3. Jamie Carragher - Liverpool - RB
A Reds legend, Carragher spent his entire career at the club, making over 500 appearances. He's now a columnist and TV pundit. Photo: Catherine Ivill
4. Danny Mills - Leeds United - RB
The tough-tackling defender now works as a pundit for various outlets. His one career trophy was a League Cup when on loan with Middlesbrough in 2014. Photo: Tom Dulat
5. Sami Hyypia - Liverpool - CB
Hyypia became a Champions League winner with the Reds in 2005. He's gone on to become a manager, and is now at the wheel of FC Zurich, having previously coached Brighton and Bayer Leverkusen. Photo: Mike Hewitt
6. Rio Ferdinand - Leeds United - CB
Ferdinand famously left the Whites to join Manchester United, and went on to win six Premier League trophies and a Champions League in 2007/08. He's now a leading pundit for BT Sport. Photo: Charlie Crowhurst