Their meeting at Elland Road will be the first time the two teams have met in the Premier League since 2004, but there have been other clashes in the years since.
The most memorable for Leeds fans is undoubtedly the 1-0 FA Cup upset at Old Trafford in 2010, with Jermaine Beckford scoring the decisive goal.
Click and scroll through to see what the Whites’ lineup from that day are up to now:
7. Andy Hughes
Hughes made over 100 appearances for the Whites in three years at Elland Road, but his most recent role was at another Yorkshire giant. The ex-midfielder was part of Garry Monk's staff at Sheffield Wednesday, but left the Owls last month when Tony Pulis took over. (Photo by Michael Regan/Getty Images) Photo: Michael Regan
8. Bradley Johnson
Johnson has carved out a very decent career for himself in the Football League since he left Elland Road in 2011. The 33-year-old has played for Norwich City, Derby County, and currently, Blackburn Rovers. (Photo by Alex Livesey/Getty Images) Photo: Alex Livesey
9. Neil Kilkenny
Kilkenny has represented Australia 13 times at senior international level, and is currently plying his trade in the A-League for Perth Glory. The midfielder was released by Melbourne City in 2018, but didn't have to wait too long to find himself a new club. (Photo by Alex Livesey/Getty Images) Photo: Alex Livesey
10. Luciano Becchio
Becchio was a firm favourite with Leeds fans during his five years at Elland Road. The hitman made a brief foray into coaching at CD Atletico Baleares, but seems to have found his calling now as a football agent, working with talent from his home country of Argentina. (Photo by Laurence Griffiths/Getty Images) Photo: Laurence Griffiths
11. Jermaine Beckford
Beckford was the hero of the hour against Man United a decade ago, and he is still very much a favourite among Leeds fans. The striker works as a pundit with Sky Sports now, and has his own weekly podcast, Doing a Leeds, with actor Matthew Lewis. (Photo by Alex Livesey/Getty Images) Photo: Alex Livesey