Scrum-half Aidan Sezer (hand injuiry) and prop Matt Prior (suspended) are ruled out from the team which beat Castleford Tigers last week.
With four props, both half-backs and their first-choice hooker all unavailable, Rhinos are down to the bare bones.
Coach Rohan Smith has named a 20-man squad, but what could his matchday 17 look like? Here's a prediction.
13. Loose-forward: Cameron Smith.
Man of the match last week and first-choice when available. Photo: Bruce Rollinson
14. Sub: Brad Dwyer.
Recalled last week and it would be harsh to leave him out. His pace could do damage if Toulouse's big men tire in the heat. Photo: Bruce Rollinson
15. Sub: Yusuf Aydin.
Signed from Wakefield Trinity on a two-week loan and will be needed as an out-and-out front-rower. Photo: Allan McKenzie/SWpix.com
17. Sub: Sam Walters.
Has done a good job as back-up prop and will be needed again. Photo: John Clifton/SWpix.com