Some key players - Jack Walker, Aidan Sezer, James Bentley, Tom Briscoe and Morgan Gannon - are unavailable, but 15 of Leeds' top 20 have been included in the initial squad.
Coach Rohan Smith will have to make at least one change, with Morgan Gannon missing because of concussion and has made it clear he isn't afraid to alter a winning side.
But after a fine performance at Warrington last week, a major reshuffle is unlikely. Here's how Rhinos could line up.
7. Richie Myler (scrum-half)
With Aidan Sezer still on the casualty list, Richie Myler is set for a third successive appearance at scrum-half. Photo: Alex Whitehead/SWpix.com
8. Mikolaj Oledzki (prop)
The England man has been consistently strong for Leeds this season. Photo: Tony Johnson
9. Kruise Leeming (hooker)
Rhinos are a much better team with Kruise Leeming at hooker and he faces a big task agianst Giants' Danny Levi. Photo: Bruce Rollinson
10. Zane Tetevano (prop)
Could continue after having a strong game as a starting prop last week. Photo: Tony Johnson
11. Bodene Thompson (second-row)
Was excellent at Warrington as a starting second-row and deserves to retain the spot. Photo: Bruce Rollinson
12. Rhyse Martin (second-row)
Morgan Gannon is unavailable so, with Harry Newman back in the squad, the logical move is for Rhyse Martin to resume his specialist role. Photo: Alex Whitehead/SWpix.com