Rhinos will be boosted by the return of half-back Aidan Sezer (groin injury), hooker Kruise Leeming (illness) and second-row James Bentley (suspension), but that means some difficult decisions for coach Rohan Smith.
He has confirmed Sezer will start, so where Richie Myler - who can play at half, full-back or, at a push, as hooker - fits into the team is one of the most intriguing selection posers.
Here's how Rhinos could line up as they bid to end a 10-game losing run against the reigning champions.
13. Cameron Smith (loose-forward)
Has started at 13 most weeks when fit and available. Photo: Bruce Rollinson
14. Richie Myler (substitute)
Brad Dwyer or Jarrod O'Connor could also get the nod as replacement hooker. It would be tough to leave Dwyer out, but Myler's versatility might swing it. Photo: Bruce Rollinson
15. Matt Prior (substitute)
Picked up a sternum injury playing for Combined Nations last weekend, but is hopeful of being available. Photo: Bruce Rollinson
16. Bodene Thompson (substitute)
Had some good games recently and could play in the front- or back-row. Photo: Bruce Rollinson
17. James Donaldson (substitute)
Experience and a bit of versatility could secure him the final spot. Photo: Bruce Rollinson