United are expected to name a largely unchanged XI against the Canaries at Carrow Road but will be forced into one potentially significant change in the middle of the park.
Ampadu will sit out the next 10 weeks of Championship action after picking up a lateral collateral knee ligament injury against Coventry last weekend. In his place, Ilia Gruev will reprise his role as the 'deep six' leaving the question of whether Joe Rothwell or Ao Tanaka comes into the side for a prolonged spell.
Daniel Farke threw his support behind Mateo Joseph once more in Monday's pre-match press conference following another goal off the bench from Joel Piroe.
Leeds' defensive options now appear decidedly light after it was revealed Wober would undergo knee surgery on an injury to his meniscus.
Here is the starting line-up we expect Farke to name on Tuesday evening.
1. GK: Illan Meslier
Five clean sheets in seven is hard to argue with, even if he hasn't exactly been peppered with shots of late. Photo: Stu Forster
2. RB: Jayden Bogle
A real threat last Saturday and arguably his best performance in a white shirt so far. | Getty Images
3. CB: Joe Rodon
With limited options at centre-back, Leeds will be sure to wrap Wales international Rodon in cotton wool before, during and after Tuesday night's fixture. | Getty Images
4. CB: Pascal Struijk
Reported a mild adductor issue following the Cardiff City game but came through 90 minutes against Coventry. Likely to take the armband in Ampadu's absence. Photo: Ryan Hiscott
5. LB: Junior Firpo
Playing with strapping on his leg, but playing nonetheless. Firpo has ten open-play assists in the Championship throughout 2024 and is a key threat for Leeds. | Getty Images
6. CM: Ilia Gruev
The Bulgarian will drop into the 'deep six' role in Ampadu's prolonged absence. | Getty Images