Marcelo Bielsa's Whites stormed to a superb ninth-placed finish upon their top-flight return last season and their second term back in the country's top division will start with a trip to arch rivals Manchester United over the opening weekend of August 14.
A home clash against Everton is next on the agenda, followed by a trip to Burnley and then a home date against Liverpool.
Following the release of the new fixtures, we take a look at the Premier League' s betting market for the 2021-22 season and see where Leeds are ranked and on that basis where they are predicted to finish.
Our list runs in descending order, starting with the division's big outsiders. Who will go down?
7. 14th - Newcastle United
The Magpies are one of three sides on offer at 999-1 and 200s is the shortest it gets. The Toon Army are joint fifth-favourites to go down at 37-13.
8. 13th - Wolves
Wolves are also 999-1 to win the division but are as short as 150s. The Molineux outfit are eighth favourites for relegation at 6-1.
9. 12th - Brighton
The Seagulls are also on offer at 999-1 but are as short as 100s elsewhere. Brighton are 9s (tenth in the list) to go down.
10. 11th - West Ham United
David Moyes has signed a new deal but the Hammers are only 11th in the pecking order at 219-1. West Ham are 12th favourites to go down at 11s.
11. 10th - Aston Villa
Villa are next in the list at 200-1 to win the league and also ninth favourites to go down at 8s.
12. 9th - Everton
Carlo Ancelotti has gone and the Toffees are predicted to miss out on a European spot again as they are ninth favourites at 199-1. Everton are 25-1 to go down.