Marcelo Bielsa's Whites stormed to a superb ninth-placed finish upon their top-flight return last season and their second term back in the country's top division will start with a trip to arch rivals Manchester United over the opening weekend of August 14.
A home clash against Everton is next on the agenda, followed by a trip to Burnley and then a home date against Liverpool.
Following the release of the new fixtures, we take a look at the Premier League' s betting market for the 2021-22 season and see where Leeds are ranked and on that basis where they are predicted to finish.
Our list runs in descending order, starting with the division's big outsiders. Who will go down?
13. 8th - Leeds United
Fresh from their superb ninth-placed finish upon their top-flight return, Leeds are now eighth in the betting market for next season's Premier League at 150-1. The Whites are 11th-favourites to go down at 10s and only 9-2 to end up in the top six.
14. 7th - Leicester City
The Foxes are seventh in the list and only marginally shorter than Leeds at 109-1. Leicester are also 66-1 to go down.
15. 6th - Arsenal
Better is expected from the Gunners who are sixth in the market at 80-1 to win the league. If it all goes wrong, Arsenal are 66-1 for relegation.
16. 5th - Tottenham Hotspur
A step forward is also expected from Spurs who are fifth favourites at 49-1.
17. 4th - Manchester United
The Red Devils might have been runners-up last season but they are only fourth favourites at 21-2.
18. 3rd - Liverpool
The 2019-20 Premier League champions are third favourites for the 2021-22 title at 11-2.